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Article

Molecular analysis of a new variant of the CBF beta-MYH11 gene fusion.

Leukemia & lymphoma - 1 Oct 2002

Stulberg Jennifer, Kamel-Reid Suzanne, Chun Kathy, Tokunaga Jason, Wells Richard A

Abstract excerpt

The inv(16)(p13q22) is observed in 16% of patients with acute myelogenous leukemia (AML). It is classically found in the AML M4Eo subtype, which has distinctive morphological abnormalities in the bone marrow including myelomonocytic differentiation and an increase in atypical bone marrow eosinophils. A gene fusion involving CBFbeta and MYH11 is invariably created by the inv(16)(p13q22) and is thought to be a...

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Share to Alternative Splicing
Share to Chromosome Breakage
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12481902
DOI: 10.1080/1042819021000015989-1

Genes

MYH11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Molecular analysis of a new variant of the CBF beta-MYH11 gene fusion.PMID 12481902Read ↗

Molecular identification of CBFbeta-MYH11 fusion transcripts in an AML M4Eo patient in the absence of inv16 or other abnormality by cytogenetic and FISH analyses--a rare occurrence.Semantic proximity Read ↗

Rare CBFB-MYH11 fusion transcripts in AML with inv(16)/t(16;16) are associated with therapy-related AML M4eo, atypical cytomorphology, atypical immunophenotype, atypical additional chromosomal rearrangements and low white blood cell count: a study on 162 patientsSemantic proximity Read ↗

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inv(16)/t(16;16) acute myeloid leukemia with non-type A CBFB-MYH11 fusions associate with distinct clinical and genetic features and lack KIT mutations.Semantic proximity Read ↗

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Identification of the chimeric protein product of the <i>CBFB‐MYH11</i> fusion gene in inv(16) leukemia cellsSemantic proximity Read ↗

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