Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.

doi:10.1006/jaut.1996.0054

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Article

Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.

Journal of autoimmunity - 1 Jun 1996

Vafiadis P, Bennett S T, Colle E, Grabs R, Goodyer C G, Polychronakos C

Abstract excerpt

One of the loci encoding susceptibility to insulin-dependent diabetes mellitus (IDDM) is IDDM2, mapped to a variable number of tandem repeats (VNTR) polymorphism situated 596 bp upstream of the insulin gene (INS). The shorter alleles (class I) predispose to IDDM, while the longer class III allele...

Topics

Alleles
Child, Preschool
Diabetes Mellitus, Type 1
Fetus
Gene Expression
Genomic Imprinting
Genotype
Haplotypes
Humans
Infant
Insulin
Insulin-Like Growth Factor II
Leukocytes
Minisatellite Repeats
Pancreas

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