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Article

Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.

Journal of autoimmunity - 1 Jun 1996

Vafiadis P, Bennett S T, Colle E, Grabs R, Goodyer C G, Polychronakos C

Abstract excerpt

One of the loci encoding susceptibility to insulin-dependent diabetes mellitus (IDDM) is IDDM2, mapped to a variable number of tandem repeats (VNTR) polymorphism situated 596 bp upstream of the insulin gene (INS). The shorter alleles (class I) predispose to IDDM, while the longer class III alleles are protective. Besides INS, it is possible that transcription levels of IGF2, the nearby gene encoding the...

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Source

Identifiers

PMID: 8816977
DOI: 10.1006/jaut.1996.0054

Genes

IGF2
INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.PMID 8816977Read ↗

Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.Semantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.Semantic proximity Read ↗

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.Semantic proximity Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

The INS 5' variable number of tandem repeats is associated with IGF2 expression in humans.Semantic proximity Read ↗

Associations between a fetal imprinted gene allele score and late pregnancy maternal glucose concentrations.Semantic proximity Read ↗

Associations between the maternal circulating lipid profile in pregnancy and fetal imprinted gene alleles: a cohort study.Semantic proximity Read ↗

The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect.Semantic proximity Read ↗

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