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Article

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.

Human molecular genetics - 12 Dec 2000

Stead J D, Buard J, Todd J A, Jeffreys A J

Abstract excerpt

The insulin minisatellite or variable number of tandem repeats locus (INS VNTR) is the best candidate for the type 1 diabetes mellitus (T1DM) susceptibility locus IDDM2. Small class I alleles associate with predisposition to T1DM, whereas large class III alleles associate with dominant protection. We have analysed variant repeat distribution within the minisatellite and combined this with flanking haplotypes to...

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Share to Amino Acyl-tRNA Synthetases
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Heterozygote

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Source

Identifiers

PMID: 11115836
DOI: 10.1093/hmg/9.20.2929

Genes

IGF2
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes.PMID 11115836Read ↗

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.Semantic proximity Read ↗

IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.Semantic proximity Read ↗

Global haplotype diversity in the human insulin gene region.Semantic proximity Read ↗

Structural analysis of insulin minisatellite alleles reveals unusually large differences in diversity between Africans and non-Africans.Semantic proximity Read ↗

Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.Semantic proximity Read ↗

Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes.Semantic proximity Read ↗

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.Semantic proximity Read ↗

A functional analysis of the role of IGF2 in IDDM2-encoded susceptibility to type 1 diabetes.Semantic proximity Read ↗

Insulin gene 5' flanking polymorphism. Length of class 1 alleles in number of repeat units.Semantic proximity Read ↗

Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene.Semantic proximity Read ↗

Linkage disequilibrium in the insulin gene region: size variation at the 5' flanking polymorphism and bimodality among "class I" alleles.Semantic proximity Read ↗

Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function.Semantic proximity Read ↗

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