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Selection against the Dihydrofolate Reductase-Thymidylate Synthase ( DHFR-TS ) Locus as a Probe of Genetic Alterations in Leishmania major

1 Oct 1996

Abstract excerpt

The genome of the trypanosomatid protozoan genus Leishmania has been shown to undergo a number of changes relevant to drug resistance and virulence, such as gene amplification, chromosomal rearrangement, and variation in ploidy. Experimental approaches to the study of genomic changes have in some cases been limited by the fact that Leishmania cells are asexual diploids, as are some other trypanosomatids,...

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PMID: 8816478
DOI: 10.1128/mcb.16.10.5655

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