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Article

Knockout of the dhfr-ts gene in Trypanosoma cruzi generates attenuated parasites able to confer protection against a virulent challenge.

PLoS neglected tropical diseases - 1 Dec 2011

Perez Brandan Cecilia, Padilla Angel M, Xu Dan, Tarleton Rick L, Basombrio Miguel A

Abstract excerpt

BACKGROUND: Trypanosoma cruzi is a protozoan parasite that causes severe disease in millions of habitants of developing countries. Currently there is no vaccine to prevent this disease and the available drugs have the consequences of side effects. Live vaccines are likely to be more effective in inducing protection than recombinant proteins or DNA vaccines; however, safety problems associated to their use have...

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Identifiers

PMID: 22180798
DOI: 10.1371/journal.pntd.0001418
PMCID: PMC3236718

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