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Article

Alternative splicing determines the binding of platelet-derived growth factor (PDGF-AA) to glycosaminoglycans.

Biochemistry - 17 Sept 1996

Lustig F, Hoebeke J, Ostergren-Lundèn G, Velge-Roussel F, Bondjers G, Olsson U, Rüetschi U, Fager G

Abstract excerpt

We have shown previously that the platelet-derived growth factor (PDGF) and a synthetic oligopeptide, corresponding to the basic carboxyl-terminal amino acid extension of the long PDGF-A isoform, bind to heparin. Here, we have expressed the long (rA125) and the short (rA109) variants of PDGF A-chains in Escherichia coli and produced the functional homodimers. Surface plasmon resonance analyses showed that while...

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PMID: 8810913
DOI: 10.1021/bi960118l

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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