Article
Identification of three amino acid residues in the B-chain of platelet-derived growth factor with different importance for binding to PDGF alpha- and beta-receptors.
FEBS letters - 6 May 1996
Kreysing J, Ostman A, van de Poll M, Bäckström G, Heldin C H
Abstract excerpt
The B-chain homodimer isoform of platelet-derived growth factor (PDGF) binds with high affinity both to alpha- and to beta-receptors. In order to localize amino acid residues in PDGF-BB of differential importance for the binding to the two receptors, PDGF-BB mutants were analyzed in which single...
Topics
- Amino Acid Sequence
- Amino Acids
- Animals
- Binding Sites
- Binding, Competitive
- Cell Line
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Platelet-Derived Growth Factor
- Protein Binding
- Protein Conformation
- Receptor, Platelet-Derived Growth Factor alpha
- Receptor, Platelet-Derived Growth Factor beta
- Receptors, Platelet-Derived Growth Factor
- Recombinant Proteins