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Establishment of Bcgr congenic mice and their susceptibility/resistance to mycobacterial infection.

Veterinary microbiology - 1 May 1996

Xu D L, Goto Y, Amoako K K, Nagatomo T, Fujita T, Shinjo T

Abstract excerpt

Bcg congenic mice were developed by using C57BL/6 and DBA/2 strains of mice as progenitors. They were obtained by introgressively backcrossing the Bcgr marker of DBA/2 onto C57BL/6. After twenty successive backcrossings, the heterozygous resistant mice were mated with each other to obtain homozygous mice as the Bcgr congenic mice. The results of immunogenic and genetic markers coupled with those of an mixed...

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PMID: 8810009
DOI: 10.1016/0378-1135(95)00198-0

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