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Article

Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals?

BMC immunology - 9 Jul 2004

McClelland Erin E, Damjanovich Kristy, Gardner Kyle, Groesbeck Zack J, Ma Maggie S, Nibley Megan, Richardson Kelly S, Wilkinson Maureen, Morrison Linda C, Bernhardt Paul, Potts Wayne K

Abstract excerpt

BACKGROUND: Congenic strains of mice are assumed to differ only at a single gene or region of the genome. These mice have great importance in evaluating the function of genes. However, their utility depends on the maintenance of this true congenic nature. Although, accumulating evidence suggests that congenic strains suffer genetic divergence that could compromise interpretation of experimental results, this...

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Identifiers

PMID: 15245582
DOI: 10.1186/1471-2172-5-14
PMCID: PMC481063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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