Article
A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains.
Journal of neuroimmunology - 1 Jul 1992
Shaw M K, Kim C, Ho K L, Lisak R P, Tse H Y
Abstract excerpt
Adoptive EAE was induced in SJL mice by the transfer of MBP-primed and in vitro-stimulated donor lymph node cells into naive syngeneic recipients. Priming donor mice with OVA instead of restimulating MBP-primed donor cell with OVA resulted in no transfer of EAE. This apparent lack of disease, how...
Topics
- Animals
- Antigens
- Autoimmune Diseases
- Encephalomyelitis, Autoimmune, Experimental
- Female
- Genetic Predisposition to Disease
- Lymph Nodes
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Neurologic Mutants