Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lack of clinical significance of variability in the internal ribosome entry site of hepatitis C virus.

Journal of medical virology - 1 Mar 2004

Thelu Marie-Ange, Drouet Emmanuel, Hilleret Marie-Noëlle, Zarski Jean-Pierre

Abstract excerpt

The extreme 5'-proximal sequence of the hepatitis C virus (HCV) genome including the 5' non-coding region (5'NCR) of 341 nucleotide long and the first 30 nucleotides of the core region is highly conserved among different HCV genotypes. It contains a segment termed Internal Ribosome Entry Site (IRES) that regulates the cap-independent translation of HCV-RNA to polyprotein. Sequence variability in this region has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Codon, Initiator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-alpha

Share to Interferon alpha-2

Share to Nucleic Acid Conformation

Share to Protein Biosynthesis

Share to Regulatory Sequences, Nucleic Acid

Share to Ribavirin

Source

Identifiers

PMID: 14748063
DOI: 10.1002/jmv.20021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lack of clinical significance of variability in the internal ribosome entry site of hepatitis C virus.PMID 14748063Read ↗

Understanding the potential of hepatitis C virus internal ribosome entry site domains to modulate translation initiation via their structure and functionSemantic proximity Read ↗

Analysis of natural variants of the hepatitis C virus internal ribosome entry site reveals that primary sequence plays a key role in cap-independent translation.Semantic proximity Read ↗

Internal initiation of translation efficiency in different hepatitis C genotypes isolated from interferon treated patients.Semantic proximity Read ↗

Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon.Semantic proximity Read ↗

HCVIVdb: The hepatitis-C IRES variation database.Semantic proximity Read ↗

The hepatitis C virus internal ribosome-entry site: a new target for antiviral researchSemantic proximity Read ↗

A mutational shift from domain III to II in the internal ribosome entry site of hepatitis C virus after interferon-ribavirin therapy.Semantic proximity Read ↗

Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA.Semantic proximity Read ↗

A Phylogenetically Conserved Stem-Loop Structure at the 5′ Border of the Internal Ribosome Entry Site of Hepatitis C Virus Is Required for Cap-Independent Viral TranslationSemantic proximity Read ↗

Positional effect of mutations in 5'UTR of hepatitis C virus 4a on patients' response to therapy.Semantic proximity Read ↗

Characterizing the function and structural organization of the 5' tRNA-like motif within the hepatitis C virus quasispecies.Semantic proximity Read ↗

Involvement of the 5' proximal coding sequences of hepatitis C virus with internal initiation of viral translation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.