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Article

Molecular basis for the binding of SH3 ligands with non-peptide elements identified by combinatorial synthesis.

Chemistry & biology - 1 Aug 1996

Feng S, Kapoor T M, Shirai F, Combs A P, Schreiber S L

Abstract excerpt

BACKGROUND: Protein-structure-based combinatorial chemistry has recently been used to discover several ligands containing non-peptide binding elements to the Src SH3 domain. The encoded library used has the form Cap-M1-M2-M3-PLPPLP, in which the Cap and Mi's are composed of a diverse set of organic monomers. The PLPPLP portion provided a structural bias directing the non-peptide fragment Cap-M1-M2-M3 to the SH3...

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PMID: 8807900
DOI: 10.1016/s1074-5521(96)90134-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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