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Article

A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.

The EMBO journal - 1 Feb 2002

Hwang Peter M, Li Chengjun, Morra Massimo, Lillywhite Jennifer, Muhandiram D Ranjith, Gertler Frank, Terhorst Cox, Kay Lewis E, Pawson Tony, Forman-Kay Julie D, Li Shun-Cheng

Abstract excerpt

The SH2 domain protein SAP/SH2D1A, encoded by the X-linked lymphoproliferative (XLP) syndrome gene, associates with the hematopoietic cell surface receptor SLAM in a phosphorylation-independent manner. By screening a repertoire of synthetic peptides, the specificity of SAP/SH2D1A has been mapped and a consensus sequence motif for binding identified, T/S-x-x-x-x-V/I, where x represents any amino acid. Remarkably,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11823424
DOI: 10.1093/emboj/21.3.314
PMCID: PMC125837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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