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Article

Structure-based redesign of the binding specificity of anti-apoptotic Bcl-x(L).

Journal of molecular biology - 9 Jan 2013

Chen T Scott, Palacios Hector, Keating Amy E

Abstract excerpt

Many native proteins are multi-specific and interact with numerous partners, which can confound analysis of their functions. Protein design provides a potential route to generating synthetic variants of native proteins with more selective binding profiles. Redesigned proteins could be used as research tools, diagnostics or therapeutics. In this work, we used a library screening approach to reengineer the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23154169
DOI: 10.1016/j.jmb.2012.11.009
PMCID: PMC3557458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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