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Article

NorA plasmid resistance to fluoroquinolones: role of copy number and norA frameshift mutations.

Antimicrobial agents and chemotherapy - 1 Jul 1996

Sun L, Sreedharan S, Plummer K, Fisher L M

Abstract excerpt

Staphylococcus aureus NorA protein is a transmembrane multidrug efflux pump that confers low-level resistance to hydrophilic fluoroquinolones. The norA gene promoter is active in Escherichia coli HB101. We have examined the genetic basis of norA-mediated resistance in E. coli by introducing a wild-type norA gene into HB101 in plasmid pCL1921, pBR322, or pUC18 exhibiting copy numbers that spanned a 22-fold range....

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Identifiers

PMID: 8807059
DOI: 10.1128/AAC.40.7.1665
PMCID: PMC163392

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