Article
NorA plasmid resistance to fluoroquinolones: role of copy number and norA frameshift mutations.
Antimicrobial agents and chemotherapy - 1 Jul 1996
Sun L, Sreedharan S, Plummer K, Fisher L M
Abstract excerpt
Staphylococcus aureus NorA protein is a transmembrane multidrug efflux pump that confers low-level resistance to hydrophilic fluoroquinolones. The norA gene promoter is active in Escherichia coli HB101. We have examined the genetic basis of norA-mediated resistance in E. coli by introducing a wil...
Topics
- Anti-Infective Agents
- Bacterial Proteins
- Base Sequence
- Cloning, Molecular
- Drug Resistance, Microbial
- Escherichia coli
- Fluoroquinolones
- Frameshift Mutation
- Gene Amplification
- Genes, Bacterial
- Molecular Sequence Data
- Phenotype
- Plasmids
- Promoter Regions, Genetic
- Staphylococcus aureus