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Article

Allele-based analysis revealed the critical functions of region 277-297 in the NorA efflux pump of Staphylococcus aureus.

The Journal of antimicrobial chemotherapy - 12 May 2021

Shang Yan, Lv Peiwen, Li Shannan, Wang Wenkai, Liu Yuanxiang, Yang Chunyu

Abstract excerpt

OBJECTIVES: The NorA efflux pump in Staphylococcus aureus mediates resistance to many fluoroquinolone (FQ) antibiotics. Three norA alleles with high sequence similarity are found in various S. aureus strains exhibiting different FQ resistance profiles. This study aimed to elucidate the underlying molecular basis for the varying efflux activity of these three allelic variations. METHODS: The norA genotypes of 20...

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PMID: 33677568
DOI: 10.1093/jac/dkab066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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