Article
Transcriptional and post-transcriptional regulation of PenA β-lactamase in acquired Burkholderia pseudomallei β-lactam resistance.
Scientific reports - 13 Jul 2018
Chirakul Sunisa, Norris Michael H, Pagdepanichkit Sirawit, Somprasong Nawarat, Randall Linnell B, Shirley James F, Borlee Bradley R, Lomovskaya Olga, Tuanyok Apichai, Schweizer Herbert P
Abstract excerpt
Therapy of Burkholderia pseudomallei acute infections is largely limited to a few β-lactam antibiotics such as ceftazidime or meropenem. Although relatively rare, resistance emergence during therapy leads to treatment failures with high mortality rates. In the absence of acquired external resistance determinants in B. pseudomallei emergence of β-lactam resistance is invariably caused by mutational modification of...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Burkholderia pseudomallei
- Ceftazidime
- Gene Duplication
- Gene Expression Regulation, Bacterial
- Genes, Bacterial
- Host-Pathogen Interactions
- Humans