Article
Positive and negative association of HLA-DR genotypes with Japanese rheumatoid arthritis.
Clinical and experimental rheumatology - 1 Jan 2000
Takeuchi F, Nakano K, Matsuta K, Nabeta H, Bannai M, Tanimoto K, Ito K
Abstract excerpt
OBJECTIVE: To clarify the relationship between the HLA-DR genotype and susceptibility to rheumatoid arthritis (RA) in Japanese patients. METHODS: HLA-DR typing and DRB1* genotyping were carried out by PCR and PCR-SSCP (single stranded DNA conformation polymorphism), respectively. RESULTS: In RA, the prevalence of HLA-DR4 was significantly higher (57.3%, p < 0.05). In particular, DRB1*0405 was predominantly higher...
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