Article
HLA-DR antigens and HLA-DQ beta chain polymorphism in susceptibility to rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Jul 1990
Ilonen J, Reijonen H, Arvilommi H, Jokinen I, Möttönen T, Hannonen P
Abstract excerpt
Forty four patients with rheumatoid arthritis (RA) were studied for HLA-DR antigens and for HLA-DQ beta chain gene restriction fragment length polymorphism using DNA hybridisation. A significant increase in the prevalence of the DR4 antigen and a tendency towards an increase of DR1 was found in patients with RA. No allelic form of HLA-DQ restriction fragment length polymorphism patterns was increased, but the...
Topics
- Arthritis, Rheumatoid
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DR Antigens
- Humans
- Polymorphism, Restriction Fragment Length