Article
Association of specific amino acid sequence (QRRAA) of HLA-DRB1*0405 with rheumatoid arthritis in a Tunisian population.
Archives de l'Institut Pasteur de Tunis - 1 Jan 2010
Dhaouadi T, Sfar I, Abdelmoula L, Bardi R, Jendoubi-Ayed S, Makhlouf M, Aouadi H, Ben Abdallah T, Zouari R, Ayed K, Lakhoua-Gorgi Y
Abstract excerpt
This study aimed to investigate HLA-DRB1 alleles in rheumatoid arthritis (RA) patients from Tunisia and to examine the effect of these alleles on disease severity. HLA-DRBI alleles and sub-typing of DRBI*04 and *01 were determined in 90 patients and 100 healthy controls, by PCR-SSP. HLA-DRB1*04 was significantly higher in patients (51.1%) than in controls (27%) [OR=2.83, p=0.00066]. DRBJ*0405 was found to be the...
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