Article
Characterization of different soluble TNF receptor (TNFR80) derivatives: positive influence of the intracellular domain on receptor/ligand interaction and TNF neutralization capacity.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jun 1996
Moosmayer D, Wajant H, Gerlach E, Schmidt M, Brocks B, Pfizenmaier K
Abstract excerpt
Different soluble human TNFR80 derivatives, a solubilized form of the complete TNFR80, the TNFR80 extracellular domain, a secretory TNFR80 mutant (TR80TM-) with a deleted transmembrane region, and a TNFR80 immunoadhesin were produced in insect cells and characterized side by side with a recombinant human TNFR60 extracellular domain with respect to TNF binding affinity and neutralization of TNF bioactivity. The...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.