Article
Tumor necrosis factor receptor signaling. A dominant negative mutation suppresses the activation of the 55-kDa tumor necrosis factor receptor.
The Journal of biological chemistry - 5 Mar 1992
Tartaglia L A, Goeddel D V
Abstract excerpt
To investigate the signaling mechanism of the 55-kDa tumor necrosis factor (TNF) receptor a functional transfection based assay was developed. The human 55-kDa TNF receptor, stably expressed in mouse L929 cells, was demonstrated to be activated specifically by agonist antibodies and to initiate a signal for cellular cytotoxicity. A deletion mutant of the human TNF receptor lacking most of the cytoplasmic domain...
Topics
- Animals
- Cell Line
- Cell Survival
- Gene Expression
- Genetic Vectors
- Humans
- Mice
- Mutation
- Receptors, Cell Surface
- Receptors, Tumor Necrosis Factor
- Recombinant Proteins