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Article

Identification of nuclear localization signals within the zinc fingers of the WT1 tumor suppressor gene product.

FEBS letters - 9 Sept 1996

Bruening W, Moffett P, Chia S, Heinrich G, Pelletier J

Abstract excerpt

WT1 encodes a zinc finger protein with a key role in urogenital development that is inactivated in a subset of Wilms' tumors. This tumor suppressor gene product contains an amino-terminal dimerization domain required for trans-inhibition of wild-type WT1 activity by mutants defective for DNA binding. In the course of characterizing truncation mutants of WT1, we noted that the WT1 zinc fingers contain two...

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Identifiers

PMID: 8804420
DOI: 10.1016/0014-5793(96)00853-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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