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Article

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Patek C E, Little M H, Fleming S, Miles C, Charlieu J P, Clarke A R, Miyagawa K, Christie S, Doig J, Harrison D J, Porteous D J, Brookes A J, Hooper M L, Hastie N D

Abstract excerpt

The Wilms tumor-suppressor gene, WT1, plays a key role in urogenital development, and WT1 dysfunction is implicated in both neoplastic (Wilms tumor, mesothelioma, leukemias, and breast cancer) and nonneoplastic (glomerulosclerosis) disease. The analysis of diseases linked specifically with WT1 mutations, such as Denys-Drash syndrome (DDS), can provide valuable insight concerning the role of WT1 in development and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10077614
DOI: 10.1073/pnas.96.6.2931
PMCID: PMC15872

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome.PMID 10077614Read ↗

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A review of the phenotypic variation due to the Denys-Drash syndrome-associated germline WT1 mutation R362X.Semantic proximity Read ↗

Novel WT1 mutation (C388Y) in a female child with Denys-Drash syndrome.Semantic proximity Read ↗

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Exploring the Multifaceted Role of WT1 in Kidney Development and DiseaseSemantic proximity Read ↗

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