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Article

Human DNA topoisomerases II alpha and II beta can functionally substitute for yeast TOP2 in chromosome segregation and recombination.

Molecular & general genetics : MGG - 27 Aug 1996

Jensen S, Redwood C S, Jenkins J R, Andersen A H, Hickson I D

Abstract excerpt

The ability of the human DNA topoisomerase II alpha and II beta isozymes to complement functional defects conferred by conditional top2 mutations in Saccharomyces cerevisiae has been investigated. At the restrictive temperature, top2 strains show multiple abnormalities, including an inability to...

Topics

Antigens, Neoplasm
DNA Topoisomerases, Type II
DNA-Binding Proteins
Gene Expression
Genetic Complementation Test
Humans
Isoenzymes
Meiosis
Mutation
Poly-ADP-Ribose Binding Proteins
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Spores, Fungal

Temperature

Transformation, Genetic

Source

Identifiers

PMID: 8804406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8804406-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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