Article
Sequences responsible for intracellular localization of beta-actin messenger RNA also affect cell phenotype.
The Journal of cell biology - 1 Oct 1994
Kislauskis E H, Zhu X, Singer R H
Abstract excerpt
We have characterized the structure and function of RNA sequences that direct beta-cytoplasmic actin mRNA to the cell periphery were mapped to two segments of 3'-untranslated region by expression of LacZ/beta-actin chimeric mRNAs in chicken embryo fibroblasts (CEFs). A 54-nt segment, the "RNA zip...
Topics
- Actins
- Animals
- Base Sequence
- Cell Membrane
- Cells, Cultured
- Chick Embryo
- Cytoskeleton
- Humans
- Molecular Sequence Data
- Nucleic Acid Conformation
- Oligonucleotides, Antisense
- Phenotype
- Pseudopodia
- RNA, Messenger
- Sequence Homology, Nucleic Acid
- Thionucleotides
- Transfection