Trials of the beta model for complex inheritance.

doi:10.1073/pnas.93.17.9177

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Article

Trials of the beta model for complex inheritance.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Collins A, MacLean C J, Morton N E

Abstract excerpt

Theoretical advantages of nonparametric logarithm of odds to map polygenic diseases are supported by tests of the beta model that depends on a single logistic parameter and is the only model under which paternal and maternal transmissions to sibs of specified phenotypes are independent. Although it does not precisely describe recurrence risks in monozygous twins, the beta model has greater power to detect family...

Topics

Alleles
Causality
Diabetes Mellitus, Type 1
Evaluation Studies as Topic
Genetic Diseases, Inborn
Genetic Linkage
HLA Antigens
Humans
Models, Genetic
Risk Factors
Statistics, Nonparametric

Twins, Monozygotic

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