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Article

APC mutations in colorectal tumors with mismatch repair deficiency.

20 Aug 1996

Abstract excerpt

We have investigated the influence of genetic instability [replication error (RER) phenotype] on APC (adenomatous polyposis coli), a gene thought to initiate colorectal tumorigenesis. The prevalence of APC mutations was similar in RER and non-RER tumors, indicating that both tumor types share this step in neoplastic transformation. However, in a total of 101 sequenced mutations, we noted a substantial excess of...

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Identifiers

PMID: 8799152
DOI: 10.1073/pnas.93.17.9049

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