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Article

In vitro stability of APC gene sequences and the influence of DNA repair status.

Mutagenesis - 1 Mar 2012

Turnbull Charlotte L, Bacon Andrea L, Dunlop Malcolm G, Farrington Susan M

Abstract excerpt

APC is a key 'gatekeeper' gene in colorectal tumorigenesis. The high frequency of APC defects observed in colorectal cancer tissue is the result of selective growth advantage of cells with loss-of-function mutations at that locus. However, mutations may also arise due to inherent sequence instability. Defective DNA mismatch repair (MMR) and base excision repair (BER) also contribute to colorectal carcinogenesis...

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Identifiers

PMID: 22294772
DOI: 10.1093/mutage/ger069

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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