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Article

Identification of a region within the ErbB2/HER2 intracellular domain that is necessary for ligand-independent association.

The Journal of biological chemistry - 9 Aug 2002

Penuel Elicia, Akita Robert W, Sliwkowski Mark X

Abstract excerpt

Ligand-independent ErbB2 activation occurs principally by two distinct mechanisms: overexpression and mutation. Overexpression of ErbB2 at the plasma membrane drives receptor self-association in a concentration-dependent manner, which in turn leads to constitutive receptor activation. Subsets of human breast cancers contain a molecular alteration that leads to erbB2 gene amplification and subsequent protein...

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Identifiers

PMID: 12000754
DOI: 10.1074/jbc.M202510200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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