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Article

Control of Cajal body number is mediated by the coilin C-terminus.

Journal of cell science - 15 Jan 2003

Shpargel Karl B, Ospina Jason K, Tucker Karen E, Matera A Gregory, Hebert Michael D

Abstract excerpt

Cajal bodies (CBs) are nuclear suborganelles implicated in the post-transcriptional maturation of small nuclear and small nucleolar RNAs. The number of CBs displayed by various cell lines and tissues varies, and factors that control CB numbers within a given cell have yet to be described. In this report, we show that specific regions within the C-terminus of coilin, the CB marker protein, are responsible for...

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Identifiers

PMID: 12482916
DOI: 10.1242/jcs.00211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Control of Cajal body number is mediated by the coilin C-terminus.PMID 12482916Read ↗

Self-association of coilin reveals a common theme in nuclear body localization.Semantic proximity Read ↗

A point mutation in human coilin prevents Cajal body formation.Semantic proximity Read ↗

Cajal bodies and histone locus bodies in Drosophila and Xenopus.Semantic proximity Read ↗

Cajal body formation is regulated by coilin SUMOylation.Semantic proximity Read ↗

Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere lengthSemantic proximity Read ↗

Coilin is essential for Cajal body organization in Drosophila melanogaster.Semantic proximity Read ↗

In Vivo Analysis of Cajal Body Movement, Separation, and Joining in Live Human CellsSemantic proximity Read ↗

Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.Semantic proximity Read ↗

Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenanceSemantic proximity Read ↗

Cajal bodies in neuronsSemantic proximity Read ↗

The <i>Drosophila melanogaster</i> Cajal bodySemantic proximity Read ↗

Coilin displays differential affinity for specific RNAs in vivo and is linked to telomerase RNA biogenesis.Semantic proximity Read ↗

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