Article
An antifibrinolytic mechanism describing the prothrombotic effect associated with factor VLeiden.
The Journal of biological chemistry - 20 Sept 1996
Bajzar L, Kalafatis M, Simioni P, Tracy P B
Abstract excerpt
Factor Va is the essential cofactor in prothrombinase-dependent activation of prothrombin. Resistance of Factor VaLeiden to inactivation by activated protein C (APC) contributes to thrombotic tendencies in subjects with the variant due, in part, to the inability to terminate thrombin production w...
Topics
- Carboxypeptidase B2
- Carboxypeptidases
- Factor V
- Factor Va
- Fibrinolysis
- Humans
- Models, Biological
- Mutation
- Protein C
- Thrombosis