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Article

Thrombomodulin-dependent effect of factor VLeiden mutation on factor XIII activation.

Thrombosis research - 1 Apr 2012

Koncz Zsuzsa, Bagoly Zsuzsa, Haramura Gizella, Mezei Zoltán A, Muszbek László

Abstract excerpt

INTRODUCTION: Factor V Leiden mutation (FV(Leiden)) is associated with impaired down-regulation of activated FV procoagulant activity and loss of FV anticoagulant function that result in an increased risk of venous thromboembolism. As the downstream effects of FV(Leiden) on clot formation and fibrinolyis have only partially been revealed, we investigated its effect on the activation of factor XIII (FXIII) and the...

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PMID: 21774968
DOI: 10.1016/j.thromres.2011.06.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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