Article
Type 5 adenylyl cyclase disruption alters not only sympathetic but also parasympathetic and calcium-mediated cardiac regulation.
Circulation research - 22 Aug 2003
Okumura Satoshi, Kawabe Jun-ichi, Yatani Atsuko, Takagi Gen, Lee Ming-Chih, Hong Chull, Liu Jing, Takagi Ikuyo, Sadoshima Junichi, Vatner Dorothy E, Vatner Stephen F, Ishikawa Yoshihiro
Abstract excerpt
In a genetically engineered mouse line with disruption of type 5 adenylyl cyclase (AC5-/-), a major cardiac isoform, there was no compensatory increase in other isoforms of AC in the heart. Both basal and isoproterenol (ISO)-stimulated AC activities were decreased by 30% to 40% in cardiac membranes. The reduced AC activity did not affect cardiac function (left ventricular ejection fraction [LVEF]) at baseline....
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