Measuring gene-disease association using a general pair method.

Abstract excerpt

The general-pair-method (GPM) was applied to the analysis of the Problem 1 data set. GPM is a nonparametric, identity-by-state method for associating variation at a chromosomal locus with disease status. It can accommodate information from all pairs of individuals across any degree of genetic relatedness, including genetically unrelated individuals, within a single test statistic. Pairwise contrasts between...

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