Article
Genotypic association analysis using discordant-relative-pairs.
Annals of human genetics - 1 Jan 2009
Yan T, Yang Y-N, Cheng X, DeAngelis M M, Hoh J, Zhang H
Abstract excerpt
In practice, family-based design has been widely used in disease-gene association analysis. The major advantage of such design is that it is not subject to spurious association due to population structure such as population stratification (PS) and admixture. A disadvantage is that parental genotypes are hard to obtain if the disease is late onset for which a discordant-relative-pair design is useful. Designs of...
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