Article
Genome scanning for complex disease genes using the transmission/disequilibrium test and haplotype-based haplotype relative risk.
Genetic epidemiology - 1 Jan 1995
Matise T C
Abstract excerpt
Two tests for allelic association were applied to a simulated complex disease for the Genetic Analysis Workshop 9. The transmission/disequilibrium test [Spielman et al., 1993] and the haplotype-based haplotype relative risk approach [Terwilliger and Ott, 1992] were used to detect disease-associat...
Topics
- Alleles
- Chi-Square Distribution
- Chromosome Mapping
- Computer Simulation
- Genetic Diseases, Inborn
- Genetic Markers
- Genome, Human
- Haplotypes
- Humans
- Linkage Disequilibrium
- Predictive Value of Tests
- Risk Assessment