Article
Modeling the role of two susceptibility loci by the MASC method.
Genetic epidemiology - 1 Jan 1995
Dizier M H, Babron M C, Clerget-Darpoux F
Abstract excerpt
Two susceptibility genes, in linkage disequilibrium with alleles of the markers D1G31 and D5G23, have been identified for the disease in the simulated data set of Problem 1. Here we apply the MASC (marker association segregation chi-square) method to model the joint effect of these two genes, by testing two-locus models. The model we obtain, that is the most parsimonious and that best fits the data, corresponds...
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