Article
Modelling the major histocompatibility complex susceptibility to RA using the MASC method.
Genetic epidemiology - 1 Jan 1998
Génin E, Babron M C, McDermott M F, Mulcahy B, Waldron-Lynch F, Adams C, Clegg D O, Ward R H, Shanahan F, Molloy M G, O'Gara F, Clerget-Darpoux F
Abstract excerpt
To explain the association between HLA-DRB1 gene and rheumatoid arthritis (RA), two main hypotheses have been proposed. The first, the shared epitope hypothesis, assumes a direct role of DRB1 in RA susceptibility. The second hypothesis assumes a recessive disease susceptibility gene in linkage disequilibrium with DRB1. To investigate these two hypotheses, we analysed data on the HLA-DRB1 and TNF-LT loci in 49...
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