Article
Modelling the major histocompatibility complex susceptibility to RA using the MASC method.
Genetic epidemiology - 1 Jan 1998
Génin E, Babron M C, McDermott M F, Mulcahy B, Waldron-Lynch F, Adams C, Clegg D O, Ward R H, Shanahan F, Molloy M G, O'Gara F, Clerget-Darpoux F
Abstract excerpt
To explain the association between HLA-DRB1 gene and rheumatoid arthritis (RA), two main hypotheses have been proposed. The first, the shared epitope hypothesis, assumes a direct role of DRB1 in RA susceptibility. The second hypothesis assumes a recessive disease susceptibility gene in linkage di...
Topics
- Adolescent
- Adult
- Aged
- Alleles
- Arthritis, Rheumatoid
- Chi-Square Distribution
- Data Interpretation, Statistical
- Disease Susceptibility
- Epitopes
- Female
- Genetic Predisposition to Disease
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes