Article
Investigation of the HLA component involved in rheumatoid arthritis (RA) by using the marker association-segregation chi-square (MASC) method: rejection of the unifying-shared-epitope hypothesis.
American journal of human genetics - 1 Sept 1993
Dizier M H, Eliaou J F, Babron M C, Combe B, Sany J, Clot J, Clerget-Darpoux F
Abstract excerpt
In order to investigate the HLA component involved in rheumatoid arthritis (RA), we tested genetic models by the marker association-segregation chi 2 (MASC) method, using the HLA genotypic distribution observed in a sample of 97 RA patients. First we tested models assuming the involvement of a su...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Arthritis, Rheumatoid
- Chi-Square Distribution
- Epitopes
- Female
- Gene Expression
- Genes, MHC Class II
- Genetic Predisposition to Disease
- HLA-D Antigens
- HLA-DR Antigens
- HLA-DR1 Antigen