Article
Motor function analysis of myelin mutant mice using a rotarod.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Nov 1995
Kuhn P L, Petroulakis E, Zazanis G A, McKinnon R D
Abstract excerpt
We have examined motor control in normal and shiverer mutant mice using the rotarod assay, a forced motor activity which tests for balance and co-ordination. Shiverer mice carry a deletion of the myelin basic protein (MBP) gene, resulting in CNS dysmyelination and characteristic motor dysfunction. Homozygous mutant mice had a significant increase in cumulative falls from the rotarod relative to heterozygous mice....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.