Article
Assessment of genetic susceptibility to ethanol intoxication in mice.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Rustay Nathan R, Wahlsten Douglas, Crabbe John C
Abstract excerpt
Increased use of gene manipulation in mice (e.g., targeted or random mutagenesis) has been accompanied by increased reliance on a very few rapid and simple behavioral assays, each of which aspires to model a human behavioral domain. Yet, each assay comprises multiple traits, influenced by multiple genetic factors. Motor incoordination (ataxia), a common characteristic of many neurological disorders, may reflect...
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