Article
Motor function deficits in the 12 month-old female 5xFAD mouse model of Alzheimer's disease.
Behavioural brain research - 30 Jan 2018
O'Leary T P, Robertson A, Chipman P H, Rafuse V F, Brown R E
Abstract excerpt
Motor problems occur early in some patients with Alzheimer's disease (AD) and as the disease progresses many patients develop motor dysfunction. Motor dysfunction has been reported in some mouse models of AD, including the 5xFAD mouse, thus this model may be particularly useful for studying motor dysfunction in AD. In order to determine the extent of motor dysfunction in these mice, we tested 11-13 month old...
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