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Article

A Panel of Slow-Channel Syndrome Mice Reveals a Unique Locomotor Behavioral Signature.

Journal of neuromuscular diseases - 1 Jan 2000

Grajales-Reyes José G, García-González Aurian, María-Ríos José C, Grajales-Reyes Gary E, Delgado-Vélez Manuel, Báez-Pagán Carlos A, Quesada Orestes, Gómez Christopher M, Lasalde-Dominicci José A

Abstract excerpt

Muscle nicotinic acetylcholine receptor (nAChR) mutations can lead to altered channel kinetics and neuromuscular junction degeneration, a neurodegenerative disorder collectively known as slow-channel syndrome (SCS). A multivariate analysis using running wheels was used to generate activity profiles for a variety of SCS models, uncovering unique locomotor patterns for the different nAChR mutants. Particularly, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29036836
DOI: 10.3233/JND-170226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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