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Article

Effect of intrastriatal mesenchymal stromal cell injection on progression of a murine model of Krabbe disease.

Behavioural brain research - 1 Dec 2011

Wicks Shawna E, Londot Heaven, Zhang Bo, Dowden Jennifer, Klopf-Eiermann Jessica, Fisher-Perkins Jeanne M, Trygg Cynthia B, Scruggs Brittni A, Zhang Xiujuan, Gimble Jeffrey M, Bunnell Bruce A, Pistell Paul J

Abstract excerpt

One of a family of devastating lysosomal storage disorders, Krabbe disease is characterized by demyelination, psychosine accumulation, and inflammation. Affected infants rarely survive longer than 2 years. Using the twitcher mouse model of the disease, this study evaluated the potential of intrastriatal injection of adipose or bone marrow-derived mesenchymal stromal cells (MSCs) as a treatment option. Neonatal...

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Identifiers

PMID: 21840342
DOI: 10.1016/j.bbr.2011.07.051
PMCID: PMC3179783

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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