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Article

High-throughput screening of stem cell therapy for globoid cell leukodystrophy using automated neurophenotyping of twitcher mice.

Behavioural brain research - 1 Jan 2013

Scruggs Brittni A, Bowles Annie C, Zhang Xiujuan, Semon Julie A, Kyzar Evan J, Myers Leann, Kalueff Allan V, Bunnell Bruce A

Abstract excerpt

Globoid cell leukodystrophy (Krabbe's disease) is an autosomal recessive neurodegenerative disorder that results from the deficiency of galactosylceramidase, a lysosomal enzyme involved in active myelination. Due to the progressive, lethal nature of this disease and the limited treatment options available, multiple laboratories are currently exploring novel therapies using the mouse model of globoid cell...

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Source

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Identifiers

PMID: 22951180
DOI: 10.1016/j.bbr.2012.08.020
PMCID: PMC3482265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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