Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role.

doi:10.1007/s001250051081

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Article

Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role.

Diabetologia - 1 Nov 1998

Kalidas K, Wasson J, Glaser B, Meyer J M, Duprat L J, White M F, Permutt M A

Abstract excerpt

Insulin receptor substrate 2 (IRS-2) is a substrate of the insulin receptor and mediates the action of the insulin. Disruption of the IRS-2 gene in mice results in peripheral insulin resistance and relative insulin deficiency. It is therefore possible that defects in the IRS-2 gene contribute to...

Topics

Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 13
Diabetes Mellitus, Type 1
Europe, Eastern
Genetic Carrier Screening
Genetic Linkage
Genetic Markers
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin Receptor Substrate Proteins

Intracellular Signaling Peptides and Proteins

Jews

Mice

Microsatellite Repeats

Phosphoproteins

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 9833949
DOI: 10.1007/s001250051081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9833949-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Mapping of the human insulin receptor substrate-2 gene, identification of a linked polymorphic marker and linkage analysis in families with Type II diabetes: no evidence for a major susceptibility role.PMID 9833949Read ↗

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