Article
A large sample of finnish diabetic sib-pairs reveals no evidence for a non-insulin-dependent diabetes mellitus susceptibility locus at 2qter.
The Journal of clinical investigation - 15 Aug 1998
Ghosh S, Hauser E R, Magnuson V L, Valle T, Ally D S, Karanjawala Z E, Rayman J B, Knapp J I, Musick A, Tannenbaum J, Te C, Eldridge W, Shapiro S, Musick T, Martin C, So A, Witt A, Harvan J B, Watanabe R M, Hagopian W, Eriksson J, Nylund S J, Kohtamaki K, Tuomilehto-Wolf E, Boehnke M
Abstract excerpt
In the first reported positive result from a genome scan for non-insulin-dependent diabetes mellitus (NIDDM), Hanis et al. found significant evidence of linkage for NIDDM on chromosome 2q37 and named the putative disease locus NIDDM1 (Hanis et al. 1996. Nat. Genet. 13:161-166). Their total sample was comprised of 440 Mexican-American affected sib-pairs from 246 sibships. The strongest evidence for linkage was at...
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