Article
Genetic analyses of glucose transporter genes in French non-insulin-dependent diabetic families.
Diabetes & metabolism - 1 Apr 1997
Lesage S, Zouali H, Vionnet N, Philippi A, Velho G, Serradas P, Passa P, Demenais F, Froguel P
Abstract excerpt
Impaired glucose-stimulated insulin secretion and impaired insulin-mediated glucose uptake are both prominent phenotypic features of non-insulin-dependent diabetes mellitus (NIDDM). Membrane proteins GLUT1 (HepG2), GLUT2 (liver/islet), and GLUT4 (muscle/adipose tissue) facilitate glucose uptake into cells, and their genes are candidates for NIDDM. To assess their role in primary defects of diabetes, we performed...
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