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Article

Inactivation of mouse alpha-globin gene by homologous recombination: mouse model of hemoglobin H disease.

Blood - 1 Sept 1996

Chang J, Lu R H, Xu S M, Meneses J, Chan K, Pedersen R, Kan Y W

Abstract excerpt

We have disrupted the 5' locus of the duplicated adult alpha-globin genes by gene targeting in the mouse embryonic stem cells and created mice with alpha-thalassemia syndromes. The heterozygous knockout mice (.alpha/alpha alpha) are asymptomatic like the silent carriers in humans whereas the homo...

Topics

Animals
Crosses, Genetic
Disease Models, Animal
Fetal Blood
Fetal Death
Gene Targeting
Genes, Dominant
Genotype
Globins
Humans
Mice
Mice, Inbred C57BL
Mice, Knockout

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multigene Family

Recombination, Genetic

Sequence Deletion

Stem Cells

alpha-Thalassemia

Source

Identifiers

PMID: 8781443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8781443-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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